![]() pneumoniae strains carrying a bla OXA-48–like gene in China increased during 2018–2022 ( 3 – 6). One of the most prevalent carbapenemase genes, bla OXA-48 (oxacillin-hydrolyzing β-lactamase), is found predominantly on large and transferable plasmids in bacteria of order Enterobacterales. The production of carbapenemases is the most crucial carbapenem-resistance mechanism in gram-negative bacteria worldwide ( 2). The global spread of carbapenem-resistant Enterobacterales, particularly carbapenem-resistant Klebsiella pneumoniae (CRKP), poses a severe and ongoing public health threat because of high rates of illness and death ( 1). Our research helps identify key forces driving global spread of bla OXA-232–carrying CRKP ST15 lineage and emphasizes the importance of ongoing surveillance of epidemic CRKP. Most recent common ancestor was traced back to 2000 mutations averaged ≈1.7 per year per genome. The lineage originated in the United States, then spread to Europe, Asia, Oceania, and Africa. Analysis grouped 330 global bla OXA-232–carrying ST15 CRKP strains into 5 clades, indicating clonal transmission with small genetic distances among multiple strains. Phylogenetic and phylogeographic analyses revealed all bla OXA-232–carrying CRKP isolates belonged to ST15 lineage and exhibited multidrug resistance. pneumoniae sequence type (ST) 15 strains from 68 countries available in GenBank. To monitor global spread, we conducted a comprehensive genomic epidemiologic study comparing sequences from 21 bla OXA-232–carrying CRKP isolates from China with K. Prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) has compromised antimicrobial efficacy against severe infections worldwide. Sun) Case Western Reserve University School of Medicine, Cleveland, Ohio, USA (M.S. Sun) Hangzhou Women's Hospital, Hangzhou (L. 903 Hospital of PLA Joint Logistic Support Force, Hangzhou (Q. Ruan) Zhejiang University School of Medicine Fourth Affiliated Hospital, Hangzhou (J. He) Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou (Y. Jia) Zhejiang Provincial People's Hospital, Hangzhou (F. Jia) Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou (H. Mao) Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou (H. Shao) Shaoxing University Affiliated Hospital, Shaoxing, China (W. ![]() Jiang) Third People's Hospital of Xiaoshan District, Hangzhou (X. Ruan) Wenzhou Medical University Affiliated Wenling Hospital, Taizhou, China (T. ![]() You can check out NCSoft's financial reports on its investors' relations page.Author affiliations: Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China (Y. Let's just hope the other games still get dragged along for the ride. If the company keeps producing hits like that or Lineage 2 M every couple of years, then those records might keep falling. Lineage W is currently only available in select territories, but NCSoft plans to expand its service worldwide, including to North America and Europe, sometime this year. Operating profit for the year was about $311 million, which was still down 55% from 2020, thanks to the "pandemic bump" and Lineage 2 M providing the then-" best quarter ever." Don't worry, though - NCSoft won't need to launch a Patreon any time soon to meet costs. On a yearly basis, Aion got a boost from its classic servers, while Blade & Soul's much-lauded UE4 update did nothing to help that game's fortunes in 2021, it brought in about half the revenue it did in 2019.ĭespite Lineage W's great showing, profits and income for the year were down, due to the development and marketing costs of the title. Q4 2021 was also a down quarter for NCSoft's PC games, with just Guild Wars 2 posting numbers better than in Q3. Admittedly, those numbers are a little aberrant in the short term, and Lineage W is available on other platforms, but even going back over the prior four quarters - when there were no major mobile releases - the revenue split is roughly three-to-one in favor of mobile games. In total, mobile games accounted for 80% of NCSoft's take for the quarter. That's one mobile game accounting for nearly half of the company's revenue for the quarter.
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